Rochester Marriott Mayo Clinic Area offers contemporary deluxe accommodations in central Rochester, linked to Mayo Clinic via climate-controlled pedestrian subway and skyway. It features an indoor pool with solarium, sauna, hot tub and fitness center. Rooms at the Rochester Marriott Mayo Clinic Area are fitted with classic wooden furnishings and bright carpets. Each room includes a lounge with sofa bed. A flat-screen TV with cable channels is provided. Free WiFi is available throughout the property. Open daily for lunch and dinner, the Salut Wine Bar serves Italian food and labeled wines. Guests can also benefit from an attentive room service. Popular nearby attractions include Miracle Mile Shopping Center and Mayo Park, both within 1.2 mi from the Rochester Marriott Mayo Clinic hotel.

Located a 4-minute walk from Plummer Building, Kahler Grand Hotel offers 3-star accommodations in Rochester and features a bar. Offering a restaurant, the property also has a fitness center, as well as an indoor pool and a sauna. The property has a 24-hour front desk, a shuttle service, room service and free WiFi throughout the property. At the hotel, the rooms are equipped with a desk. All rooms will provide guests with a fridge. Mayo Civic Center is a 7-minute walk from Kahler Grand Hotel. Rochester International Airport is 8.1 miles from the property.

Hampton Inn Rochester is located in Rochester, 2.2 miles from Plummer Building and 2.4 miles from Mayo Civic Center. This 3-star hotel offers a 24-hour front desk and free shuttle service. The hotel provides an indoor pool, hot tub and room service. Selected rooms here will provide you with a kitchen with a fridge, a dishwasher and a microwave. Buffet and American breakfast options are available at the hotel. Rochester International Airport is 6.2 miles away.